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Widespread per- and polyfluoroalkyl Substance (PFAS) contamination is now gaining global attention with the release of the films “Dark Waters" and "The Devil We Know". But in fact, a perfect storm of science, medicine, and law has been building for these toxic chemicals for nearly two decades. This talk will address the health effects of these chemicals, as well as the background and current status of how these health effects are influencing the building wave of PFAS litigation.